The association of apolipoprotein-E (APOE) gene polymorphisms with coronary artery disease: a systematic review and meta-analysis

Abstract Background Numerous studies have investigated the role of apolipoprotein E ( APOE ) polymorphisms in coronary artery disease (CAD), but some controversies exist regarding outcomes as results were not consistent and remain uncertain. Therefore, present meta-analysis was conducted to evaluate association with disease. Methods All relevant published English language till August 2020 identified by searching through various electronic databases. The complete data independently extracted two researchers. analyzed using Comprehensive Meta-Analysis program MetaGenyo program. pooled odds ratio used check associations between CAD polymorphisms. following genetic models calculate ratio: ?2 vs. ?3 ?4 ?3. Results In final analysis, we include 12 polymorphism CAD. for allele higher (OR 2.00; 95% CI, 1.48–2.71). There is no statistical significant 1.38; 1.18–1.62). This analysis showed publication bias exists current meta-analysis. Conclusions Our findings suggest that appears a risk factor while beneficial alleviate risk. Trial registration Registered PROSPERO International Prospective Register Systematic Reviews. number CRD42020190464